Palmitoylethanolamide, PEA: key items presented
In the following sequence of presentations we bring to you the essence of knowledge around the body-own compound and supplement palmitoylethanolamide!
We start with the general introduction, an overview of palmitoylethanolamide, an endogenous cellular protectant in plants, invertebrates, vertebrates and humans, tested extensively since 1970 and widely available as food supplement. Its main action is analgesia ( a natural painkiller) and inhibition of chronic inflammation. However its additional properties as a cellular protectant and repairtive molecule make this natural supplement to an unique compound.
More can be found under this link (what it is, how to use it).
Palmitoylethanolamide, the essence
We follow-up with a summary of various protective mechamisms of palmitoylethanolamide (supplement PeaPure, food for medical purposes in Italy, een PEA-houdend product), explaining the anti-inflammatory and restaurative properties of this healing molecule of nature.
In the following example we show you the body-own synthesis of palmitoylethanolamide in gut tissue of colitis patients; the gut produces PEA to protect the cells against the inflammation, it is a clear axample of the self healing properties of our body. In chronic inflammation this synthesis needs extra support by administering the supplement PeaPure.
Discovery of mechanism of action of palmitoylethanolamide by Nobel Laureate prof. Rita Levi-Montalcini
Montalcini’s paper from 1993 is a hallmark paper were the Nobel price laureate for the first time one of the key regulating functions of palmitoylethanolamide ( PeaPure) discovered. Here the key messages of her insight:
In the 80s already the research group of Schmidt found clear protective effectsof PEA. Prof. Levi-Montalcini shows the results from a 2003 series experiments demonstrating the protective effect of palmitoylethanolamide in case of cell stress, comparable to inflammation, in the ischemia myocardial model.
Palmitoylethanolamide brings rest in overactivated nerve cells in pain
Palmitoylethanolamide inhibits pain and inflammation by its biological effects on so called non-neuronal cells, inflammation cells such as the mast cell, and the various glia cells. Glia plays a major role in chronic pain and these cells produces palmitoylethanolamide, our endogenous analgesic modulator as an answer to chronic pain and inflammation. By supporting these celles with exogenous palmitoylethanolamide pain can be significantly be reduced: