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Ferulic acid against painful neuropathy

Ferulic acid can kill pain and is an anti-oxidant and anti-aging compound.

Ferulic acid (FA) is a organic compound found in the seeds and leaves of most plants, especially in the brans of grasses such as wheat, rice, and oats. Its chemical structure strongly resembles that of curcumin, and it is mostly extracted from wheat bran.

In an animal model pregabalin (10 mg/kg, p.o.) and ferulic acid (10, 20, 30 mg/kg, p.o.), both significantly and dose dependently, decreased various markers for neuropathic pain: thermal hyperalgesia, mechanical hyperalgesia, and tactile allodynia) as well as a series of biochemical markers (total protein, nitric oxide, lipid peroxidase, and interleukins). [1]

The compound is produced by plants in high concentrations, when the plants are stressed, so it is a natural protective compound. [2]

In animal models for memory problems ferulic acid protects the brain. [3] It also has protective properties in diabetes models. [4]

July 2016, prof. dr. JMK Hesselink


[1] Aswar M1, Patil V2. | Ferulic acid ameliorates chronic constriction injury induced painful neuropathy in rats. | Inflammopharmacology. | 2016 Jul 2. [Epub ahead of print]

[2] Ko JY1, Ko MO1, Kim DS1, Lim SB1. | Enhanced Production of Phenolic Compounds from Pumpkin Leaves by Subcritical Water Hydrolysis. | Prev Nutr Food Sci. | 2016 Jun;21(2):132-7. doi: 10.3746/pnf.2016.21.2.132. Epub 2016 Jun 30.

[3] Yang H1, Qu Z1, Zhang J2, Huo L1, Gao J1, Gao W1. | Ferulic acid ameliorates memory impairment in d-galactose-induced aging mouse model. | Int J Food Sci Nutr. | 2016 Jun 26:1-12. [Epub ahead of print]

[4] El-Bassossy H1, Badawy D2, Neamatallah T3, Fahmy A2. | Ferulic acid, a natural polyphenol, alleviates insulin resistance and hypertension in fructose fed rats: Effect on endothelial-dependent relaxation. | Chem Biol Interact. | 2016 Jul 25;254:191-7. doi: 10.1016/j.cbi.2016.06.013. Epub 2016 Jun 7.