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Natural treatment of Parkinson with body’s own palmitoylethanolamide

The role of palmitoylethanolamide in Parkinson.

Blogged from IOCOB

Parkinson’s disease is still difficult to treat. There are substances that supplement the lack of dopamine in the brain. However these don’t treat the actual problem itself, namely the degeneration of nerve cells in part of the brain.

A new chapter has been opened since a few years, with knowledge that has been obtained about the repair mechanisms of our body. These substances responsible for repair and protection are part of the group of body’s own molecules. One of those substances available in the Netherlands and Europe is called palmitoylethanolamide. It’s available in its most pure form as PeaPure. A new 2014 study showed that 30 Parkinson patients benefited from a yearlong treatment with palmitoylethanolamide (read further).

A breakthrough was reported in 2012 when it turned out that palmitoylethanolamide can protect the nerve cells in the brain with Parkinson disease.

Palmitoylethanolamide (we will call it PEA) can be a valuable addition to the treatment of Parkinson’s disease. We will explain why below.

Because PEA is a supplement with nearly no side effects and because it’s easy to use and can be used in combination with other Parkinson medication, we will elaborate on it more. On Youtube you can see a number of Parkinson patients that were happy with the results of smoking weed. However, Cannabis is not an option if you don’t want to feel stoned. PEA works in the same way, however it doesn’t make you stoned. That’s why we are examining at this substance here.

Parkinson’s disease: inflammation in the nervous system

There’s hope again for Parkinson patients in the form of a body’s own, natural substance with the difficult name palmitoylethanolamide (supplement PeaPure).
A lot of promising results were announced, in 2014 after 30 patients with severe Parkinson’s disease were treated with this substance, on top of their dopamine preparations, for a year.

The importance of researching new ways

In the scientific journal TRENDS in pharmacological sciences (2007 Vol.28 No.4), researchers and neurologists of several Italian universities and the ‘European Centre for Brain Research (CERC)’ describe the importance of a different approach of Parkinson’s disease.

They emphasize that neurobiological research in the last years clarified that Parkinson’s disease is connected to a chronic inflammation in the nervous system. This specifically shows from the presence of activated inflammatory cells close to the nerve cells in the substantia nigra that have been affected by Parkinson’s disease. These activated inflammatory cells destroy the still present and functioning nerve cells that produce dopamine.

We see the same thing in animal models of Parkinson’s disease. Here the dopamine producing nerve cells also degenerate and researchers see a lot of activated inflammatory cells. Furthermore it shows that with certain patients the severity of the disease is closely related to the activity of the inflammatory cells and inflammatory molecules.

Experiments show that a protective effect in the dopamine producing cells, go together with a decrease of activated inflammatory cells.

Researchers describe it as follows:

More recently, the importance of neuroinflammation in PD pathophysiology has also emerged. Indeed, activated microglia have been described in close proximity to degenerating dopamine neurons in individuals with PD, and activation of microglia into the substantia nigra has been shown to cause selective destruction of dopamine neurons.

Furthermore, experimental parkinsonism, induced by neurotoxins specific to dopamine neurons, is coupled with the activation of nigral and striatal microglia and with the production of proinflammatory molecules. In addition, in models of Parkinson’s disease inhibition of microglia is neuroprotective.

As in Alzheimers disease, polymorphisms of some cytokines have been identified as risk factors for Parkinson whereas epidemiological studies have reported that chronic users of anti-inflammatory drugs have a decreased risk for Parkinsin…This protective effect is paralleled by a concomitant reduction in the associated microglial response and moderate, transient increases in cytokine levels at the sites of neurodegeneration.Therefore, modulation of the neuroprotective effect of peripheral inflammation might be exploited for improving the treatment of Parkinson’s disease.

This is why substances that inhibit this inflammatory response and protect the nervous system against further damage are so important. Our body produces substances like this as a natural healing mechanism. These are called the endocannabinoids, of which the supplement PeaPure is an example. Since 2012, endocannabinoids are considered a new possible treatment for Parkinson’s disease. [1]

Treating Parkinson’s disease with the help of the body’s own protection mechanism of endocannabinoids: the supplement palmitoylethanolamide

The authors emphasize in the article that the body’s own reparative and regenerative mechanism possesses molecules of the endocannabinoid class.

..”.we recall that the release of endocannabinoids during neuronal injury might constitute a protective response….”

This idea that endocannabinoids can be of importance in the treatment of Parkinson’s disease was also clearly voiced in the online journal ‘Brain Briefings’.

A growing body of evidence also indicates that modifying endocannabinoid levels in the brain’s striatum may help people with Parkinson’s and Huntington’s diseases. The striatum integrates signals from other brain areas, such as the substantia nigra, a central region for movement control. Scientists believe that imbalances in brain cell activity in these pathways underlie the movement deficits of these diseases. Adjusting endocannabinoid levels may help restore balance.

One of the most studied body’s own protective and regenerative substances is the endocannabinoid that goes by the name Palmitoylethanolamide. Also known as the supplement PeaPure. PeaPure only contains the bodily substance PEA and has no chemical additives.

Meanwhile there has been a number of Parkinson patients in the Netherlands, Italy and Spain who have experienced that taking this supplement contributes to better functioning and shape. Over a million patients have been treated with PEA in Europe and the substance has shown to be safe and easy to use in combination with other medicine.

Breakthrough 2012: Eposito’s conclusion

Based on an animal study, researchers concluded the following information, which speaks for itself:

Our results indicate that the PEA is neuroprotective even when administered once the insult has been initiated. This point is of particular importance, as the lack of PD biomarkers and the difficulties of early diagnosis make the pharmacotherapy of PD possible only when dopamine neuronal loss is advanced and the first symptoms have appeared.

PEA, administered once the insult has been initiated, cuts off the link inflammation-gliosis-mitochondrial dysfunction and may be represent a good neurotropic support.

A comparison of PEA against minocycline, also known having neuroprotective activity, demonstrated superior recovery in the PEA-treated animals vs minocycline-treated mice. [2]

Evaluation of PeaPure for Parkinson’s disease

A lot of research has been done on the safety and effectiveness of PeaPure for a variety of conditions. In the area of Parkinson’s disease there have been positive experiences, but no large-scale publicized studies. Because the substance is a body’s own supplement that can be used in combination with other medicine, and because there have been so many other studies with positive results, we give a green-orange light. We doubt there will ever be enough funding to organize large-scale studies, as nobody will make money on it… It is not a patented substance, but a body’s own molecule. Considering the positive results of cannabis on Parkinson’s disease, PeaPure looks like a good choice for people that don’t want to get stoned.

The use of PEA: how to utilize it for Parkinson’s disease

Since November 2012, a new supplement has been available in the Netherlands that contains only PEA. In some other supplements there are other pharmaceutical additives and sweeteners, which can cause undesired reactions (diarrhea).

PeaPure has been developed by Russel Science Ltd and is available in packets of 30 capsules of 400mg each. For Parkinson we recommend:

At least 1200mg per day, meaning 3 capsules, which can be taken together, for example two in the morning after breakfast and one in the evening after dinner. 1200 mg per day was also the dose that worked for the recent study with 30 patients with severe Parkinson. It can be useful to double the dose for several weeks to increase the effect. If there are no effects after 3 months, you can stop the treatment.

For Parkinson, use Pea for a minimum of three months. Because it doesn’t have a direct effect on dopamine levels, you will not notice an immediate effect. Rather, the effect would be more stabilizing. The first month, many patients feel a positive shift in their moods. Try it for yourself. It can’t do any harm, as PEA can be used in combination with any other medicine without problems.

Always make sure to take enough vitamin D3, especially during the winter (at least 2000 IE). In our opinion this will give an extra protection.

Additional literature on neuroinflammation

Zipp, F. and Aktas, O. (2006) The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases. Trends Neurosci. 29, 518–527
Aktas, O. et al. (2005) Neuronal damage in autoimmune neuroinflammation mediated by the death ligand TRAIL. Neuron 46, 421–432 Block, M.L. and Hong, J.S. (2005) Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog. Neurobiol. 76, 77–98
Allan, S.M. et al. (2005) Interleukin-1 and neuronal injury. Nat. Rev. Immunol. 5, 629–640 Babcock, A.A. et al. (2003) Chemokine expression by glial cells directs leukocytes to sites of axonal injury in the CNS. J. Neurosci. 23, 7922– 7930
Marchetti, B. and Abbracchio, M.P. (2005) To be or not to be (inflamed) – is that the question in anti-inflammatory drug therapy of neurodegenerative disorders? Trends Pharmacol. Sci. 26, 517–525



[1] Morera-Herreras T, Miguelez C, Aristieta A, Ruiz-Ortega JÁ, Ugedo L. | Endocannabinoid modulation of dopaminergic motor circuits. | Front Pharmacol. | 2012 Jun 12;3:110. doi: 10.3389/fphar.2012.00110. eCollection 2012.
[2] Esposito E, Impellizzeri D, Mazzon E, Paterniti I, Cuzzocrea S. | Neuroprotective activities of palmitoylethanolamide in an animal model of Parkinson’s disease. | PLoS One. |2012;7(8):e41880. doi: 10.1371/journal.pone.0041880. Epub 2012 Aug 17.