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Palmitoylethanolamide, safety and efficacy articles and reviews from professor JMK Hesselink, MD

In 2010 in Athens at the 3rd International Congress on Neuropathic Pain Keppel Hesselink identified a remarkable poster in the basements of the congres. It was a poster from the group of professor Cruccu in Rome, and the poster described the clinical findings in diabetic neuropathy of a hitherto to him and all his English speaking colleagues unknown natural compound, palmitoylethanolamide (PEA). Prof. Keppel Hesselink worked as a VP many years at Bayer AG, and was responsable for the world wide development of CNS drugs. He said that never in his carrier he came across a molecule so interesting as PEA.

Palmitoylethanolamide: amazing compound

This compound had amazing clinical effects and a remarkable safety and tolerability profile. It has been known before in oldfashioned matrix tablet and suspension formulation, but since 2007 it was available in an improved formulation: micro-PEA, specially designed to improve the bioavailability of PEA (currently available as formulations containing micronized PEA-m, ultramicronized PEA-um or optimized PEA-opt).

Palmitoylethanolamide had been in the dark since clinical work started with the compound in the 70s of last century, because nearly all research and development was done in Italy, and no clinical data were published in English.

Keppel Hesselink’s goal was to disclose this unique natural compound for the clinical world, since its first identification as an analgesic in 1966. He did so with a number of publications from 2011 onwards, all referred to in this entry.

Micro-PEA: new PEA formulation in specific formulations

Therefore he started in 2010 to work with the compound in his institute, treated many hundreds of patients with formulations containing micro-PEA, and published a great number of original articles, case-reports, clinical trials and reviews on this compound we summarize here for you in this entry, including links to most of the original papers.