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Topical Phenytoin cream and the identification of responders and placebo responders

At the European Pain Federation (EFIC) at Copenhagen, September 2017, we could present our placebo response test at the workshop on placebo and nocebo responders.

This workshop on ‘the state of the art, prediction and ethical considerations’, chaired by Dr Vase, the first presenter dr Colloca from the USA reinforced such response system to identify in the clinical responders from nonr-esponders.

She also pointed out, based on our findings related to topical phenytoin cream and placebo cream, that it will be possible in such a way to easier and better identify further treatments for individual patients an easier and quicker way.

Description of Responder-test

Owing to the fast onset of action of topical analgesics, responders can be identified quickly with a test application, described in attachment 1. A positive responder-test is based on at least a 2-point pain reduction on the NRS within 30 minutes. To correct for placebo effects the responder test could be performed by also applying a placebo cream on another painful area.

September 2017, prof. dr. Jan M Keppel Hesselink, pain specialist