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Neuropathic pain research in Germany

Neuropathic pain research in Germany Doctors and researchers working in the field of neuropathic pain in Germany, are bundling insights and resources in the German Research Network on Neuropathic Pain (DFNS). The DFNS focuses on research in the field of neuropathic pain by integrating the resources of the leading centers actively involved in neuropathic pain…

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Pregabalin not effective in HIV neuropathy

Pregabalin not effective in HIV neuropathy Pregabalin was as effective as placebo and relatively well-tolerated in the treatment of painful HIV neuropathy, according to a new 2010 double-blind study. In ‘Neurology’ neurologists of the Mount Sinai School of Medicine, New York, NY, USA reported the efficacy, safety, and tolerability of Pregabalin for treatment of painful HIV-associated neuropathy.…

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Topical treatment of neuropathic pain

Topical treatment of neuropathic pain Topical analgesic creams for treatment of neuropathic pain and tingling, may have many advantages over systemic treatment with analgesics. In our Institute for Neuropathic Pain (INP) in the Netherlands, we developed various topical analgesic creams for the treatment of neuropathic pains. The development team working on these creams, consisted of…

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Statins side effects: myalgia and myopathy

Statins side effects: myalgia and myopathy Statins have more side effects than we thought, like myalgia and myopathy. Statin-associated myalgia and myopathy are the most important group of iatrogenic muscle disorders in current clinical practice. According to a recent overview (2010). The author states the importance of recognizing these forms of myopathy, as: atrogenic muscle…

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Fractalkine CX3CR1 and neuropathic pain

Fractalkine CX3CR1 and neuropathic pain Fractalkine is a remarkable chemokine constitutively expressed by neurons, and its only receptor, CX3CR1, is expressed by microglia. The chemokine Fractalkine therefore is a one of the new kids on the block in neuropathic pain and is seen as a key mediator of spinal neuronal-microglial communication. Fractalkine induces migration of…

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Does cannabinoids work for neuropathic pain?

Does Cannabinoids work for neuropathic pain? Does Cannabinoids work for neuropathic pain? There is a relationship between diabetes, diabetic peripheral neuropathy (DPN) and neuropathic pain. But our understanding of underlying mechanisms leading to chronic pain in diabetes, remains poor. “Recent evidence has demonstrated a prominent role of microglial cells in neuropathic pain states. One potential…

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Propentofylline, a glia modulator

Propentofylline as a glia modulator This glia modulator, Propentofylline, is the new kid on the block for the treatment of intractable neuropathic pain. Gliopathic pain is perhaps a better term for this pain, as the winding up phenomena is very much driven by activated glia. The search for glia modulators therefore is quite exciting. We…

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Sodium creams and spray for neuropathic pain

Sodium creams and sprays for neuropathic pain Sodium creams and sprays are promising in the treatment of neuropathic pain. An Indian research group starts stating that combination of drugs with different mechanisms of action, helps in achieving synergistic analgesic effect in neuropathic pain. This is also our experience. They designed a prospective double-blind randomized placebo-controlled…

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Intravenous Ketamine for Neuropathic Pain

Intravenous Ketamine in Neuropathic Pain What can intravenous Ketamine do for neuropathic pain patients? Treatment of refractory neuropathic pain is a clinical challenge. However, many new case reports and small clinical trials suggest that the N-methyl-D-aspartic acid (NMDA) receptor antagonists Ketamine may be clinically useful in treating cases of neuropathic pain. This case report supports…

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Lyrica and Cymbalta for Fibromyalgia

Lyrica and Cymbalta for Fibromyalgia Do Lyrica ® and Cymbalta ® help for Fibromyalgia? People with Fibromyalgia have typically turned to pain medicines, anti-depressants, muscle relaxants, and sleep medicines. In June 2007, Lyrica® (Pregabalin) became the first FDA-approved drug for specifically treating Fibromyalgia. A year later, in June 2008, Cymbalta® (duloxetine hydrochloride) became the second.…

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Green light for NGF antibodies

NGF can be counteracted: green light for NGF antibodies An Advisory Panel Gives the Green Light to Restart NGF Antibodies Trials. Investigators pleased that promising agents for pain relief have new life, states a new entry. Interestingly Palmitoylethanolamide with which we work is a natural inhibitor of the effects of NGF! An advisory panel of…

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Low-grade inflammation and chronic pain

Low-grade inflammation and chronic pain Low-grade inflammation is thought to play a role in the pathophysiology of chronic pain conditions. This is the reason why increasing numbers of pain physicians use the anti-inflammatory compound Palmitoylethanolamide (PEA). Previous human plasma/serum and/or cerebrospinal fluid (CSF) cytokine studies have only looked at a few predetermined cytokine candidates. The…

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Psoriasis: a new innovative approach

Psoriasis: a new innovative approach There is new innovative approach for Psoriasis. Pruritus is an important symptom in psoriasis. Gamma aminobutyric acid (GABA) is an important neurotransmitter that regulates neuronal excitability in the nervous system. The GABA receptors (R) are classified into GABA, GABA and GABA types. The GABA ligand and its GABAA R may…

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Glia modulators for neuropathic pain

Glia modulators for neuropathic pain Since 1994 when Meller and colleagues for the first time demonstrated that by inhibiting astrocyte functions, neuropathic pain did not emerge, many glia modulators have been explored as new inroads in the treatment of neuropathic pain. Some specifically inhibit cytokines (like Il-18), others enhance anti-inflammatory cytokines, such as Il-10, and…

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Nitrates in neuropathic pain?

Nitrates in neuropathic pain? The Indian group of Agrawal and colleagues (2007) explored the analgesic effects of glyceryl nitrates spray in neuropathic pain. They suggested that impaired nitric oxide (NO) synthesis may play an important role in the pathogenesis of painful diabetic neuropathy. Some studies demonstrated impaired neuronal nitric oxide generation in diabetic rats induces…

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Visceral pain: a forgotten topic

Visceral pain: a forgotten topic Prof. Fernando Cervero from Montreal, Canada discussed at the EFIC 2013 in Florence an under served but very important topic, which is visceral pain. Visceral pain is very under served. As patients often visit organ specialists not interested in pain itself, but directly focusing on the underlying illness. However, as…

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No new analgesics in 50 years

No new analgesics in 50 years Yes, there hasn’t been any new development of analgesics during the last 50 years. Quite a provocative title! A single author article in one of the leading journals for anesthesiologists specializing in the treatment of pain. What does the author exactly say? A lack of real breakthrough drugs He…

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Publications about Phenytoin for pain

Publications about Phenytoin for pain An overview of publications about Phenytoin for neuropathic pain. Fabry’s Disease, Dysesthesia (Painful Touching), Tabes, Post-Herpetic Neuralgia, Refractory Chronic Pain, Pain in Multiple Sclerose, Reflex Sympathetic Dystrophy, Abdominal Pain, Analgesia. Neuropathy 3249. Wiffen, P., McQuay, H., Carroll, D., Jadad, A., and Moore, A., Anticonvulsant drugs for the management of acute…