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Treatment of CIAP, pain, instability and tiredness

Here we present a patient suffering from CIAP with neuropathic pain, and gait instability, as well as complaints of tiredness:

Despite intensive investigation 10–40% of patients with peripheral neuropathy referred to neurologists lack a causative diagnosis, and the diagnosis in those cases is CIAP, chronic idiopathic axonal polyneuropathy. Most of CIAP patients patients have a slowly progressive axonal sensory and motor or purely sensory neuropathy without pain. However, pain is a recurrent symptom in the patients refered to our Institute for treatment. The term CIAP was first used by the Utrecht neurologists Notermans et al.

Literature on CIAP

Notermans NC, Wokke JHJ. Chronic idiopathic axonal polyneuropathy. Muscle Nerve 1996; 19: 1637–8.

Notermans NC, Wokke JHJ, Franssen H, van der Graaf Y, Vermeulen M, van den Berg LH, et al. Chronic idiopathic polyneuropathy presenting in middle or old age: a clinical and electrophysiological study of 75 patients. J Neurol Neurosurg Psychiatry 1993; 56: 1066–71.

Notermans NC, Wokke JHJ, van der Graaf Y, Franssen H, van Dijk GW, Jennekens FGI. Chronic idiopathic axonal polyneuropathy: a five year follow up. J Neurol Neurosurg Psychiatry 1994; 57: 1525–7.