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Hoge dosis vitamine D zijn veilig

De vraag was: zijn hoge doseringen vitamine D veilig en eventueel zinvol voor MS patienten?: Are high doses of vitamin D safe and potentially therapeutic for patients with multiple sclerosis (MS)?

In een studie van een jaar lang werden aan 25 MS patienten ultrahoge doseringen vitamine D gegeven, samen met calcium:[1]

In the year long open-label randomized trial, 25 MS patients received an escalated dose of vitamin D up to 40,000 IU over the first 28 weeks of the study (to assess tolerability) and then the dose was lowered to 10,000 IU for an additional 12 weeks, followed by a further decrease back to 0 by the end of the year. A control group of 24 MS patients took no or low doses (up to 4,000 IUs daily) of vitamin D. A daily dose of calcium (1,200 mg/d) was given throughout the study, the investigators reported online April 28 in advance of the print edition of Neurology.

Die hoge doseringen bleken veilig te zijn volgens de onderzoekster:

Dr. Burton and her colleagues reported that vitamin D levels, even at those high levels, were safe and calcium levels were not abnormally altered. “That is always a concern when you deliver high doses of vitamin D,” she said. 

De studie was slechts klein en niet bedoeld om te onderzoeken of hoge doses vitamine D ook daadwerkelijk zinvol waren voor MS patienten:

Dr. Burton said that although the study “was not powered or blinded to properly address clinical outcomes, clinical outcomes appeared to favor the treatment groups.” Specifically, they reported that T-cell reactivity and proliferation dropped in treated patients. In addition, there was a 41 percent reduction in relapse rates in the treated group compared with a 17 percent reduction in controls who were allowed to take up to 4,000 IUs of vitamin D daily. 

Bron: Vitamin D in High Doses Found Safe — with Potential Benefits for MS, Neurology Today 10(11) June 2010: 27-28

Juni 2010 Jan M. Keppel Hesselink, en David J. Kopsky, artsen

Referentie

[1] Burton JM, Kimball S, Vieth R, Bar-Or A, Dosch HM, Cheung R, Gagne D, D'Souza C, Ursell M, O'Connor P. | A phase I/II dose-escalation trial of vitamin D3 and calcium in multiple sclerosis. | Neurology. | 2010 Jun 8;74(23):1852-9. Epub 2010 Apr 28.