Anodyne Therapy System® for neuropathy: not proven!
Surfing the net you may encounter many different treatments for neuropathy, and the anodyne therapy is one of those. In the internet you may find advertorials like the following: f you suffer from diabetic neuropathy, you may benefit from Anodyne Therapy--a non-invasive treatment that increases circulation and reduces the pain associated with peripheral neuropathy. The Anodyne Therapy System® helps to release nitric oxide from the red blood cells of patients suffering from diabetes. It does this with monochromatic infrared energy (MIRE) administered through flexible pads containing infrared diodes.
It all sounds great, but in essence there is not one methodological sound clinical trial to substantiate these claims, that is to date. The claims mostly are as broad as trodden yoguhrt on the road, folwlwing an old quote by Goethe. Here an example:
Because Anodyne Therapy can
- restore sensation in patients with neuropathy, as well as
- reducing pain and
- increasing nerve conduction and healing,
diabetics suffering from neuropathy can benefit greatly by the treatments. It is equally useful for people with chronic conditions or acute conditions associated with pain, numbness, poor circulation, lingering wounds or other maladies involving the circulatory system.
We have not copme across any publiched paper supporting these claims. Moreover, there has been published a recent trial demonstrating that the Anodyne treatment did not differentiate from placebo in the treatment of diabetic neuropathy: Anodyne MIRE therapy was no more effective than sham therapy in the treatment of sensory neuropathy in individuals with diabetes.  An earlier trial with less patients was positive, it was a small and methodological weak trial. 
April 2010, Jan M. Keppel Hesselink, MD, PhD