Home > Algemeen > Wetenschap > Potentiele huidindicaties voor palmitoylethanolamide

Potentiele huidindicaties voor palmitoylethanolamide

Enkele huidaandoeningen waarbij de behandeling van een PEA-houdend product zinvol kan zijn op basis van de pathogenese van deze aandoeningen en in het licht van de werking van palmitoylethanolamide op de mestcel.

Huidaandoeningen

Chronische onbegrepen huidontstekingen [1] [2] [3] [4] [5]

Chronische onbegrepen jeuk [6] [7]

Atopische en contactdermatitis [8] [9] [10] [11]

Psoriasis [12] [13] [14]

Referentie

[1] De Filippis D, Luongo L, Cipriano M, Palazzo E, Cinelli MP, de Novellis V, Maione S, Iuvone T. | Palmitoylethanolamide reduces granuloma-induced hyperalgesia by modulation of mast cell activation in rats. | Mol Pain. | 2011 Jan 10;7:3.

[2] Petrosino S, Iuvone T, Di Marzo V. | N-palmitoyl-ethanolamine: Biochemistry and new therapeutic opportunities. | Biochimie. | 2010 Jun;92(6):724-7. Epub 2010 Jan 21.

[3] Endocannabinoid Research Group, De Filippis D, D'Amico A, Cipriano M, Petrosino S, Orlando P, Di Marzo V, Iuvone T. | Levels of endocannabinoids and palmitoylethanolamide and their pharmacological manipulation in chronic granulomatous inflammation in rats. | Pharmacol Res. | 2010 Apr;61(4):321-8. Epub 2009 Nov 17.

[4] Hoareau L, Buyse M, Festy F, Ravanan P, Gonthier MP, Matias I, Petrosino S, Tallet F, d'Hellencourt CL, Cesari M, Di Marzo V, Roche R. | Anti-inflammatory effect of palmitoylethanolamide on human adipocytes. | Obesity (Silver Spring). | 2009 Mar;17(3):431-8. Epub 2009 Jan 8.

[5] De Filippis D, D'Amico A, Cinelli MP, Esposito G, Di Marzo V, Iuvone T. | Adelmidrol, a palmitoylethanolamide analogue, reduces chronic inflammation in a carrageenin-granuloma model in rats. | J Cell Mol Med. | 2009 Jun;13(6):1086-95. Epub 2008 Apr 18.

[6] Machelska H. | Dual peripheral actions of immune cells in neuropathic pain. | Arch Immunol Ther Exp (Warsz). | 2011 Feb;59(1):11-24. Epub 2011 Jan 14.

[7] Ständer S, Raap U, Weisshaar E, Schmelz M, Mettang T, Handwerker H, Luger TA. | Pathogenesis of pruritus. | J Dtsch Dermatol Ges. | 2011 Jun;9(6):456-463. doi: 10.1111/j.1610-0387.2011.07585.x. Epub 2011 Jan 5.

[8] Järvikallio A, Naukkarinen A, Harvima IT, Aalto ML, Horsmanheimo M. | Quantitative analysis of tryptase- and chymase-containing mast cells in atopic dermatitis and nummular eczema. | Br J Dermatol. | 1997 Jun;136(6):871-7.

[9] Eberlein B, Eicke C, Reinhardt HW, Ring J. | Adjuvant treatment of atopic eczema: assessment of an emollient containing N-palmitoylethanolamine (ATOPA study). | J Eur Acad Dermatol Venereol. | 2008 Jan;22(1):73-82.

[10] Petrosino S, Cristino L, Karsak M, Gaffal E, Ueda N, Tüting T, Bisogno T, De Filippis D, D'Amico A, Saturnino C, Orlando P, Zimmer A, Iuvone T, Di Marzo V. | Protective role of palmitoylethanolamide in contact allergic dermatitis. | Allergy. | 2010 Jun 1;65(6):698-711. Epub 2009 Nov 11.

[11] Kircik L. | A nonsteroidal lamellar matrix cream containing palmitoylethanolamide for the treatment of atopic dermatitis. | J Drugs Dermatol. | 2010 Apr;9(4):334-8.

[12] Harvima IT, Nilsson G, Naukkarinen A. | Role of mast cells and sensory nerves in skin inflammation. | G Ital Dermatol Venereol. | 2010 Apr;145(2):195-204.

[13] Kneilling M, Röcken M. | Mast cells: novel clinical perspectives from recent insights. | Exp Dermatol. | 2009 May;18(5):488-96.

[14] Harvima IT, Nilsson G, Suttle MM, Naukkarinen A. | Is there a role for mast cells in psoriasis? | Arch Dermatol Res. | 2008 Oct;300(9):461-78. Epub 2008 Aug 22.