Low-grade inflammation and chronic pain

Low-grade inflammation is thought to play a role in the pathophysiology of chronic pain conditions. This is the reason why increasing numbers of pain physicians use the anti-inflammatory compound Palmitoylethanolamide (PEA).

29027134-Cornelius20-Dreamstime-INP inflammation painPrevious human plasma/serum and/or cerebrospinal fluid (CSF) cytokine studies have only looked at a few predetermined cytokine candidates.

The aim of a number of researchers from Scandinavia was to review results from a series of recent studies that measured 92 inflammation-related proteins in chronic pain.

Studies about inflammation and pain

Human pain studies using the Proseek® Multiplex Inflammation I panel (Olink Bioscience, Uppsala, Sweden) were reviewed. The studies were by Moen et al. on chronic radicular pain (Int J Inflam 2016), Bäckryd & Tanum et al. on fibromyalgia (J Pain Res 2017), Gerdle et al., on chronic widespread pain (Medicine 2017), and Bäckryd et al. on peripheral post-traumatic neuropathic pain (manuscript, February 2017).

The researchers found a high degree of overlap across different pain conditions and across biofluids (blood/CSF).

Notably, LAPTGF-beta-1 was differentially expressed in all studied pain conditions, in both plasma/serum and in CSF. Another finding was that, using two different control groups, SIRT2, AXIN1, 4E-BP1, STAMBP, and CASP-8 were major findings in plasma from both Fibromyalgia and chronic widespread pain patients.

Their conclusion

Recent human “inflammatory fingerprint” studies confirm the presence of chronic inflammation. Ongoing low-grade inflammation may play a role in pain hypersensitivity and spread of pain, as well as concerning the “sickness syndrome” often reported by pain patients.

Source

  • P05-BASIC SCIENCE (ANATOMY, PHYSIOLOGY, PHARMACOLOGY, BEHAVIOUR): CENTRAL ​​SENSITIZATION, Abstract: 328, INCREASING EVIDENCE OF LOW-GRADE INFLAMMATION IN CHRONIC PAIN – A REVIEW OF RECENT RESULTS FROM HUMAN MULTIPLEX PROTEIN PANEL STUDIES, E. Bäckryd1, B. Gerdle1, J. Gjerstad2, T. Gordh3
  • Linköping University, IMH, Linköping, Sweden
  • University of Oslo, Molecular Biosciences, Oslo, Norway
  • Uppsala university, Surgical sciences, Uppsala, Sweden

Jan M. Keppel Hesselink, MD, PhD
‘Low-grade inflammation and chronic pain’

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