Publicaties over Fenytoine crème

Een overzicht van onze publicaties over Fenytoine crème, vanaf 2010 van Prof. dr. J.M. Keppel Hesselink en Drs. D.J. Kopsky, arts.

2019

  • Russell AL, Keppel Hesselink JM. Topical phenytoin in a case of severe fibromyalgia: ex juvantibus proof for fibromyalgia as a localized non-length dependent small fiber neuropathy. J Archives of Medical Case Reports and Case Study. 2019. Link

2018

  • Keppel Hesselink JM, Kopsky DJ. Neuropathic pain due to chronic idiopathic axonal neuropathy: fast pain reduction after topical phenytoin cream application. Open J Pain Med. 2018; 2(1): 007-008. PDF
  • Kopsky DJ, Keppel Hesselink JM. Single-blind placebo-controlled response test with phenytoin 10% cream in neuropathic pain patients. Pharmaceuticals 2018; 11: 122. PDF Link
  • Keppel Hesselink JM. Pain in chemotherapy-induced peripheral neuropathy: NGF and the logic of topical phenytoin cream. J Case Rep Clin Images. 2018; 2: 1008. PDF
  • Bartollino S, Chiosi F, di Staso S, Uva M, Pascotto A,Rinaldi M, Keppel Hesselink JM, Costagliola C. The retinoprotective role of phenytoin. Drug Des Devel Ther. 2018;12: 3343-3356. PDF
  • Keppel Hesselink JM. Chronobiology of neuropathic pain and the use of topical phenytoin in painful diabetic neuropathy. J Diabetol 2018; 2(2): 3-5. PDF Link
  • Keppel Hesselink JM. Phenytoin cream in painful diabetic neuropathy: an evolving chapter. J Diabetol 2018; 2(2): 6-8. PDF Link
  • Keppel Hesselink JM. A case of wasp-induced pain treated with topical phenytoin cream. J Clin Cases Rep 2018; 1(3): 106-108. PDF
  • Kopsky DJ, Keppel Hesselink JM. A single-blind n-of-1 study evaluating 4 different doses of phenytoin in a topical analgesic cream for the treatment of peripheral neuropathic pain. J Pain Manage Ther. 2018;2(1):17-20. PDF Link
  • Keppel Hesselink JM, Kopsky DJ. Fast onset of relief after topical phenytoin in neuropathic pain after chemotherapy. Trends Cancer Res Chemother. 2018;1(1):1-3. PDF
  • Keppel Hesselink JM. Posttranslational sodium ion channel modifications and the use of topical phenytoin in Painful Diabetic Neuropathy (PDN). Int J Diabetes Metab Disord 2018; 3(1)1-3. PDF
  • Keppel Hesselink JM, Notermans NC. Topical phenytoin formulations for pain in small fiber neuropathy, a pathogenetic approach. Gen Int Med Clin Innov. 2018; 3(1): 2-4. PDF
  • Kopsky DJ, Keppel Hesselink JM. Phenytoin Cream for the Treatment of Neuropathic Pain: Case Series. Pharmaceuticals (Basel). 2018;11(2): E53. PDF Link
  • Keppel Hesselink JM. How to Define Neuroprotection: The Case of Phenytoin. Open Access J Neurol Neurosurg. 2018; 7(4): 555719. PDF
  • Keppel Hesselink JM. Topical Nav1.7 channel blocker failed in postherpetic Neuralgia (PHN): lessons to learn. Gen Med Open. 2018; 2(2): 1-2. PDF
  • Keppel Hesselink JM, Kopsky DJ. The individualized N-of-1 trial: dose-response in a single-blind cross-over response test of phenytoin 10% and 30% cream in neuropathic pain. EC Anaesthesia 2018; 4(6):1-6. PDF
  • Keppel Hesselink JM, Mulder JK, Kopsky DJ. Rationale for the repositioning of phenytoin as a topical analgesic for peripheral neuropathic pain and a personalized and investigator-driven development plan. Ann Pharmacol Pharm. 2018; 3(2): 1144. PDF
  • Keppel Hesselink JM. Single-blind placebo-controlled response on phenytoin 10% in painful diabetic neuropathy. Gen Med Open. 2018; 2(1): 2-3. PDF
  • Kopsky DJ, Keppel Hesselink JM. Phenytoin in topical formulations augments pain reduction of other analgesics in the treatment of neuropathic pain. Int J Anesthetic Anesthesiol 2018; 5: 061. PDF
  • Keppel Hesselink JM. Topical phenytoin in painful diabetic neuropathy: rationale to select a non-selective sodium channel blocker. Clinical research in Neurology. 2018; 1(1): 1-5. Link
  • Keppel Hesselink JM. Phenytoin cream in painful diabetic neuropathy: support for development of new indications for generic drugs needed. Austin Neurology 2018; 3(1): 1011. Link
  • Keppel Hesselink JM. Phenytoin: repurposing an old molecule and patent strategies for neuropathic pain. J Clin Trials Pat 2018;3(1): 3. PDF Link
  • Keppel Hesselink JM, Kopsky DJ. Small fiber burning pain in diabetic neuropathy in the elderly, treated with phenytoin cream. BAOJ Anesthesia 2018; 2(1): 003. PDF Link

2016-2017

  • Keppel Hesselink JM. Topical Amitriptyline: can it reduce localized neuropathic pain? J Clin Trials Regul Aff. 2017; 1(1): 1-4. Link
  • Keppel Hesselink JM, Kopsky DJ. Topical compounded analgesic treatment in neuropathic pain: 8 years of experience. J Pain Manage Med. 2017;3(2): 128. PDF Link
  • Keppel Hesselink JM. Rethinking peripheral sensitization, peripheral neuropathic pain and the putative value of topical analgesics. J of Pharmacol & Clin Res. 2017; 4(2): 555631. PDF
  • Keppel Hesselink JM. Repurposing phenytoin as an anti-aggression drug: clinical evidence. Neurol Disord Therap 2017; 1(4)1-5. PDF
  • Keppel Hesselink JM, Kopsky DJ. Topical phenytoin cream in small fiber neuropathic pain: fast onset of perceptible pain relief. Int J Pain Relief. 2017;1(1): 015-019. PDF
  • Keppel Hesselink JM, Kopsky DJ. Topical analgesia: transdermal or ‘intradermal’ mechanisms of action? Sci J Neurol Neurosurg. 2017;3(3): 066-069. PDF
  • Keppel Hesselink JM, Kopsky DJ. Phenytoin cream reduces pain and improves sleep in patients suffering from neuropathic pain. Austin J Anesthesia and Analgesia. 2017; 5(2): 1061. PDF
  • Keppel Hesselink JM, Kopsky DJ. Pain in chemotherapy induced peripheral neuropathy treated with topical phenytoin cream. CP Cancer Sci. 2017 1(2): 008. PDF
  • Keppel Hesselink JM. Phenytoin repositioned in wound healing: clinical experience spanning 60 years. Drug Discov Today. 2017 Oct 6. Link
  • Chiosi F, Keppel Hesselink JM, Rinaldi M, Di Staso S, Bartollino S, Costagliola C. Phenytoin: its potential as neuroprotective and retinoprotective drug. Br J Clin Pharmacol. 2017 Oct 12. Link
  • Keppel Hesselink JM. Phenytoin: a step by step insight into its multiple mechanisms of action-80 years of mechanistic studies in neuropharmacology. J Neurol. 2017; 264(9), 2043-2047. Link
  • Keppel Hesselink JM, Kopsky DJ. Phenytoin: neuroprotection or neurotoxicity? Neurol Sci. 2017 Jun;38(6):1137-1141. Link
  • Keppel Hesselink JM, Kopsky DJ. Topical phenytoin cream reduces burning pain due to small fiber neuropathy in sarcoidosis. J Anesth Pain Med. 2017; 2(1): 1-3. PDF Link
  • Keppel Hesselink JM. Amantadine and phenytoin: patent protected cases of drug repositioning Clin Invest. 2017; 7(1):11-16. Link
  • Keppel Hesselink JM, Kopsky DJ. Bottlenecks in the development of topical analgesics: molecule, formulation, dose finding, and phase III design. J Pain Res. 2017; 10: 635-641. PDF Link
  • Keppel Hesselink JM, Kopsky DJ. Burning pain in small fibre neuropathy treated with topical phenytoin: rationale and case presentations. J Clin Anesth Pain Med. 2017; 1(1): 6. PDF Link
  • Kopsky DJ, Keppel Hesselink JM. Phenytoin in topical formulations augments pain reduction of other topically applied analgesics in the treatment of trigeminal neuralgia. J. Clin Anesth. 2017; 38: 154-155. Link
  • Keppel Hesselink JM, Kopsky DJ. Topical phenytoin in neuralgic pain, peripheral modulation of central sensitization: two case reports. J Pain Relief 2017; 6(2): 284. PDF Link
  • Kopsky DJ, Keppel Hesselink JM. Topical phenytoin for the treatment of neuropathic pain. J Pain Res. 2017; 10:469-473. PDF Link
  • Keppel Hesselink JM, Kopsky DJ. Phenytoin: 80 years young, from epilepsy to breast cancer, a remarkable molecule with multiple modes of action. Journal of Neurology. 2017:1-5. Link
  • Keppel Hesselink JM, Kopsky DJ, AK Bhaskar. Skin matters! The role of keratinocytes in nociception: a rational argument for the development of topical analgesics. J Pain Res. 2017; 10:1-8. PDF. Link
  • Keppel Hesselink JM, Kopsky DJ. Topical phenytoin cream in neuropathic pain: fast onset of perceptible pain relief. Int J Pain Relief. 2017;1(1): 015-019.
  • Keppel Hesselink JM. Topical Analgesics: Critical Issues Related to Formulation and Concentration. J Pain Relief 2016, 5:6 DOI: 10.4172/2167-0846.1000274. PDF
  • Keppel Hesselink JM. Thinking out of the pillbox: the relevance to topiceuticals in the treatment of neuropathic pain. J Pain Relief 2016; 6(5): PDF. Link
  • Keppel Hesselink JM, Kopsky DJ, Sajben NL. New topical treatment of vulvodynia based on the pathogenetic role of cross-talk between nociceptors, immunocompetent cells and epithelial cells. J Pain Res. 2016; 9: 757-762. PDF Linkhttps://www.dovepress.com/articles.php?article_id=29234
  • Keppel Hesselink JM, Kopsky DJ. Topical analgesic creams and nociception in diabetic neuropathy: towards a rationale fundament. Clin Case Rep Rev. 2016; 2(7): 500-502. PDF
  • Kopsky DJ. Topical analgesia is a viable option. J Pain Relief 2016; 5(3):245. PDF
  • Kopsky DJ. Extending the therapeutic scope for the treatment of neuropathic pain with topical analgesics. J Pain Relief. 2016; 5(3): 251-252. PDF Link
  • Keppel Hesselink JM. Thinking out of the pillbox: the relevance to topiceuticals in the treatment of neuropathic pain. J Pain Relief 2016; 6(5): PDF. Link
  • Keppel Hesselink JM, Kopsky DJ, Sajben NL. New topical treatment of vulvodynia based on the pathogenetic role of cross-talk between nociceptors, immunocompetent cells and epithelial cells. J Pain Res. 2016; 9: 757-762. PDF Link

Publicaties over Fenytoine crème van 2015 en eerder

  • Kopsky DJ, Keppel Hesselink JM, Bhaskar A, Hariton G, Romanenko V, Casale R. Analgesic effects of topical Ketamine. Minerva Anestesiol. 2015;81(4):440-449. Link
  • Kopsky DJ, Keppel Hesselink JM, Casale R. Walking with Neuropathic Pain: Paradoxical Shift from Burden to Support? Case Rep Med. 2015;2015:764950. PDF Link
  • Keppel Hesselink JM, Kopsky DJ, Sajben NL. Vulvodynia and proctodynia treated with topical Baclofen 5 % and Palmitoylethanolamide. Arch Gynecol Obstet. 2014 Aug;290(2):389-93. Link
  • Keppel Hesselink JM, Kopsky DJ. Treatment of chronic regional pain syndrome type 1 with Palmitoylethanolamide and topical Ketamine cream: modulation of nonneuronal cells. J Pain Res. 2013 Mar 21;6:239-45. PDF Link
  • Kopsky DJ, Keppel Hesselink JM. Neuropathic pain as a result of acromegaly, treated with topical Baclofen cream.J Pain Symptom Manage 2013 Oct;46(4):e4-5. Link
  • Kopsky DJ, Liebregts R, Keppel Hesselink JM. Central neuropathic pain in a patiënt with multiple Sclerose treated successfully with topical Amitriptyline.Case Rep Med.2012;2012:471835. PDF Link
  • Kopsky DJ, Amelink GJ, Keppel Hesselink JM. Intractable neuropathic pain in spinal intramedullary cavernoma treated successfully with a novel combination cream. Pain Med.2012 May;13(5):729-30. PDF
  • Keppel Hesselink JM, Kopsky DJ. Intractable neuropathic pain due to ulnar nerve entrapment treated with cannabis and Ketamine 10%. J Clin Anesth. 2012 Feb;24(1):78-9. Link

Publicaties Fenytoine crème 2010-2012

  • Kopsky DJ, Keppel Hesselink JM, Bhaskar A, Hariton G, Romanenko V, Casale R. Analgesic effects of topical Ketamine. Minerva Anestesiol. 2015;81(4):440-449. Link
  • Kopsky DJ, Keppel Hesselink JM, Casale R. Walking with Neuropathic Pain: Paradoxical Shift from Burden to Support? Case Rep Med. 2015;2015:764950. PDF Link
  • Keppel Hesselink JM, Kopsky DJ, Sajben NL. Vulvodynia and proctodynia treated with topical Baclofen 5% and Palmitoylethanolamide. Arch Gynecol Obstet. 2014 Aug;290(2):389-93. Link
  • Keppel Hesselink JM, Kopsky DJ. Treatment of chronic regional pain syndrome type 1 with Palmitoylethanolamide and topical Ketamine cream: modulation of nonneuronal cells. J Pain Res. 2013 Mar 21;6:239-45. PDF Link
  • Kopsky DJ, Keppel Hesselink JM. Neuropathic pain as a result of acromegaly, treated with topical Baclofen cream.J Pain Symptom Manage 2013 Oct;46(4):e4-5. Link
  • Kopsky DJ, Liebregts R, Keppel Hesselink JM. Central neuropathic pain in a patiënt with multiple Sclerose treated successfully with topical Amitriptyline.Case Rep Med. 2012;2012:471835. PDF Link
  • Kopsky DJ, Amelink GJ, Keppel Hesselink JM. Intractable neuropathic pain in spinal intramedullary cavernoma treated successfully with a novel combination cream. Pain Med. 2012 May;13(5):729-30. PDF
  • Keppel Hesselink JM, Kopsky DJ. Intractable neuropathic pain due to ulnar nerve entrapment treated with cannabis and Ketamine 10%. J Clin Anesth. 2012 Feb;24(1):78-9. Link
  • Kopsky DJ, Keppel Hesselink JM. Multimodal Stepped Care Approach Involving Topical Analgesics for Severe Intractable Neuropathic Pain in CRPS Type 1: A Case Report. Case Rep Med. 2011;2011:319750. PDF Link
  • Kopsky DJ, Keppel Hesselink JM. High doses of topical Amitriptyline in neuropathic pain: two cases and literature review. Pain Pract. 2012 Feb;12(2):148-53. PDF Link
  • Liebregts R, Kopsky DJ, Keppel Hesselink JM. Topical Amitriptyline in post-traumatic neuropathic pain.J Pain Symptom Manage. 2011 Apr;41(4):e6-7. Link
  • Keppel Hesselink JM, Kopsky DJ. Letter to the editor. Curr Ther Res Clin Exp. 2010 Dec;71(6):416-7. PDF
  • Kopsky DJ, Keppel Hesselink JM. A new combination cream for the treatment of severe neuropathic pain. J Pain Symptom Manage. 2010 Feb;39(2):e9-e10. PDF Link
  •  
  • Kopsky DJ, Keppel Hesselink JM. Multimodal Stepped Care Approach Involving Topical Analgesics for Severe Intractable Neuropathic Pain in CRPS Type 1: A Case Report. Case Rep Med. 2011;2011:319750. PDF Link
  • Kopsky DJ, Keppel Hesselink JM. High doses of topical Amitriptyline in neuropathic pain: two cases and literature review. Pain Pract. 2012 Feb;12(2):148-53. PDF Link
  • Kopsky DJ, Liebregts R, Keppel Hesselink JM. Central Neuropathic Pain in a Patiënt with Multiple Sclerose Treated Successfully with Topical Amitriptyline.Case Report Med. 2012;2012:471835. Epub 2012 Jul 18.[1]
  • Liebregts R, Kopsky DJ, Keppel Hesselink JM. Topical Amitriptyline in post-traumatic neuropathic pain.J Pain Symptom Manage. 2011 Apr;41(4):e6-7. Link
  • Keppel Hesselink JM, Kopsky DJ. Letter to the editor. Curr Ther Res Clin Exp. 2010 Dec;71(6):416-7. PDF Link
  • Kopsky DJ, Keppel Hesselink JM. A new combination cream for the treatment of severe neuropathic pain. J Pain Symptom Manage. 2010 Feb;39(2):e9-e10. PDF Link
  • Kopsky DJ, Amelink GJ, Keppel Hesselink JM. Intractable neuropathic pain in spinal intramedullary cavernoma treated successfully with a novel combination cream. Pain Medicine 2012 May;13(5):729-30[2]
  • Keppel Hesselink JM, Kopsky DJ. Intractable neuropathic pain due to ulnar nerve entrapment treated with cannabis and Ketamine 10%. J Clin Anesth. 2012 Feb; 24(1):78-9.[3]
  • Kopsky DJ, Keppel Hesselink JM. High Doses of Topical Amitriptyline in Neuropathic Pain: Two Cases and Literature Review. Pain Pract. 2012 Feb;12(2):148-53.[4]
  • Kopsky DJ, Keppel Hesselink JM. Multimodal Stepped Care Approach Involving Topical Analgesics for Severe Intractable Neuropathic Pain in CRPS Type 1: A Case Report. Case Report Med. 2011;2011:319750.[5]
  • Liebregts R, Kopsky DJ, Keppel Hesselink JM. Topical Amitriptyline in Post-Traumatic Neuropathic Pain. J Pain Symptom Management Vol. 41, No. 4, April 2011: e6-e8 [6]
  • Keppel Hesselink JM, Kopsky DJ. Letter to the editor Ketamine 10% in CRPS). Curr Ther Res Clin Exp 2010 71(6): 416-417.
  • Kopsky DJ, Keppel Hesselink JM.A new combination cream for the treatment of severe neuropathic pain. J Pain Symptom Manage. 2010 Feb;39(2):e9-e10.[7]

Prof. dr. J.M. Keppel Hesselink, Drs. D.J. Kopsky, arts
‘Publicaties over Fenytoine crème’

 

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Referentielijst

[1] Kopsky DJ, Liebregts R, Keppel Hesselink JM. | Central Neuropathic Pain in a Patient with Multiple Sclerosis Treated Successfully with Topical Amitriptyline. | Case Report Med. | 2012;2012:471835. Epub 2012 Jul 18.

[2] Kopsky DJ, Amelink GJ, Keppel Hesselink JM. | Intractable neuropathic pain in spinal intramedullary cavernoma treated successfully with a novel combination cream. | Pain Med. | 2012 May;13(5):729-30. doi: 10.1111/j.1526-4637.2012.01362.x. Epub 2012 Apr 11.

[3] Hesselink JM, Kopsky DJ. | Intractable neuropathic pain due to ulnar nerve entrapment treated with cannabis and ketamine 10%. | J Clin Anesth. | 2012 Feb;24(1):78-9. Epub 2012 Jan 5.

[4] Kopsky DJ, Keppel Hesselink JM. | High Doses of Topical Amitriptyline in Neuropathic Pain: Two Cases and Literature Review. | Pain Pract. | 2011 Jun 16. doi: 10.1111/j.1533-2500.2011.00477.x. [Epub ahead of print]

[5] Kopsky DJ, Keppel Hesselink JM. | Multimodal Stepped Care Approach Involving Topical Analgesics for Severe Intractable Neuropathic Pain in CRPS Type 1: A Case Report. | Case Report Med. | 2011;2011:319750. Epub 2011 Oct 17.

[6] Liebregts R, Kopsky DJ, Hesselink JM. | Topical amitriptyline in post-traumatic neuropathic pain. | J Pain Symptom Manage. | 2011 Apr;41(4):e6-7.

[7] Kopsky DJ, Keppel Hesselink JM. | A new combination cream for the treatment of severe neuropathic pain. | J Pain Symptom Manage. | 2010 Feb;39(2):e9-e10.


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