Phenytoin cream reduces pain in diabetic neuropathy

In the following video a patiënt suffering from painful diabetic neuropathy explains how Phenytoin cream reduces pain. On the numerical rating scale in which 0 is no pain and 10 is severe pain (NRS), he scored his pain from 9-10 to 2-4 after application the cream.


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[1] Kopsky DJ1, Keppel Hesselink JM2. | Single-Blind Placebo-Controlled Response Test with Phenytoin 10% Cream in Neuropathic Pain Patients. | Pharmaceuticals (Basel). | 2018 Nov 12;11(4). pii: E122. doi: 10.3390/ph11040122.

[2] Keppel Hesselink JM1, Kopsky DJ2, Bhaskar AK3. | Ethical justification of single-blind and double-blind placebo-controlled response tests in neuropathic pain and N-of-1 treatment paradigm in clinical settings. | J Pain Res. | 2019 Jan 14;12:345-352. doi: 10.2147/JPR.S180792. eCollection 2019.

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