Lyrica and Cymbalta for Fibromyalgia

Do Lyrica ® and Cymbalta ® help for Fibromyalgia? People with Fibromyalgia have typically turned to pain medicines, anti-depressants, muscle relaxants, and sleep medicines.

38416920-Viorel-Dudau-Dreamstime-INP fibromyalgia lyrica cymbaltaIn June 2007, Lyrica® (Pregabalin) became the first FDA-approved drug for specifically treating Fibromyalgia. A year later, in June 2008, Cymbalta® (duloxetine hydrochloride) became the second.

Mechanism is unknown

Both Lyrica ® and Cymbalta ® reduce pain and improve function in people with Fibromyalgia. While those with Fibromyalgia have been shown to experience pain differently from other people, the mechanism by which these drugs produce their effects is unknown.

There is some data suggesting that these drugs affect the release of neurotransmitters in the brain. Neurotransmitters are chemicals that transmit signals from one neuron to another. Treatment with Lyrica ® or Cymbalta ® reduces the level of pain experienced by some people with Fibromyalgia.

Lyrica®, marketed by Pfizer Inc., was previously approved to treat seizures. As well as pain from damaged nerves that can happen in people with diabetes (diabetic peripheral neuropathy). And in those who develop pain following the rash of shingles.

Side effects

Lyrica® including sleepiness, dizziness, blurry vision, weight gain, trouble concentrating, swelling of the hands and feet, and dry mouth. Allergic reactions, although rare, can occur.

Cymbalta®, marketed by Eli Lilly and Co., was previously approved to treat depression, anxiety, and diabetic peripheral neuropathy. Cymbalta®’s side effects include nausea, dry mouth, sleepiness, constipation, decreased appetite, and increased sweating.

Like some other anti-depressants, Cymbalta® may increase the risk of suicidal thinking and behavior in people who take the drug for depression. Some people with Fibromyalgia also experience depression.

Studies of both drugs showed that a substantial number of people with Fibromyalgia received good pain relief, but there were others who didn’t benefit.

Lyrica® and Cymbalta® are approved for use in adults 18 years and older. The drug manufacturers have agreed to study their drugs in children with Fibromyalgia and in breastfeeding women.


March, Jan M. Keppel Hesselink, MD, PhD
‘Lyrica and Cymbalta for Fibromyalgia’

Watch our video’s about Neuropathy.

Vitamin D and the influence on chronic pain

Is Tapentadol better than Tramadol?
Visceral pain: a forgotten topic
Nitrates in neuropathic pain?

Mail ons voor het maken van een afspraak

Mail ons voor het maken van een afspraak

Ik ga akkoord met de privacyverklaring*