What is the definition of neuropathic pain?

What is the definition of neuropathic pain? At the Third International Congress on Neuropathic Pain in Athens, Hansson, Backonja, Bouhassira and Attal spoke about ‘How to Diagnose Neuropathic Pain’.

In the workshop it became clear that on the question “what is neuropathic pain” there was no agreement in the pain community.

67084777-Vchalup-Dreamstime-INP neuropathic pain definition

Lesion or disease?

Hansson reviewed the new definition on neuropathic pain and the graded diagnostic system proposed recently by the German group of Treede et al. 2008.

Treede stressed the fact that the diagnosis of neuropathic pain should rely on identification of a neurological lesion or disease.

The former definition of the IASP 1994 on neuropathic pain is

  • “Neuropathic pain: pain initiated or caused by a primary lesion or dysfunction in the nervous system.”

The new definition of neuropathic pain Treede introduced in 2008 along with a diagnostic workup is

  • “Pain arising as a direct consequence of a lesion or disease affecting the somatosensory system”.

Dysfunction left out

Bouhassira was not particularly happy with the Treede approach, which is characterized by a strong orientation in localized neurological thinking. In this new definition the word dysfunction is left out. As dysfunction can be seen as physiological neuroplasticity. Hence, diagnoses as CRPS, IBS and Fibromyalgia fall out of the new definition of neuropathic pain through leaving away the word dysfunction.

In the discussion Bouhassira pointed out that it is important to leave the word “dysfunction” in the definition, and therefore not to discard diseases which don’t have a clear lesion. Though are very real as schizophrenia and congenital epilepsy.

Core symptoms

Bouhassira also pointed out that one limitation of the Treede proposal is that it does not take into account the characteristics of pain. He stated that over the last years, it had become clear that neuropathic pain is characterized by the combination of a relatively small number of ‘core’ symptoms (particularly burning pain, electric shocks, dysesthesia, allodynia to brush). This distinguishes it from other types of chronic pain. 

Although none of the pain descriptors seem to be specific standing, alone studies showed consistently that the combination of a relatively small number of symptom items was sufficient to discriminate neuropathic pain from other chronic pain states. Based on these findings the development and validation of a series of simple clinical tools, in the form of questionnaires emerged, such as the DN4.

Different neuropathic pain questionnaires are developed independently and in parallel in different countries. This symptom based approach seems superior over a more anatomical based approach. Clearly there is a discrepancy at the moment between the French and the German approach how to define neuropathic pain. 


WORKSHOP SUMMARY: HOW TO DIAGNOSE NEUROPATHIC PAIN – P. Hansson 1,2, M. Backonja 3, D. Bouhassira 4
1 Department of Molecular Medicine and Surgery and Pain Center,
2 Department of Anesthesiology and Intensive Care, Karolinska University Hospital, Solna/Karolinska Institute, Stockholm, Sweden
3 Department of Neurology, University of Wisconsin-Madison, Madison, WI, USA
4 INSERM U-987, Hopital Ambroise Paré, Boulogne-Billancourt, France

June 2010, David J Kopsky, MD and J M Keppel Hesselink, MD, PhD
‘What is the definition of neuropathic pain?’

Watch our video’s about Neuropathy.

Visceral pain: a forgotten topic

Psoriasis: a new innovative approach
Glia modulators for neuropathic pain
Statins side effects: myalgia and myopathy

Mail ons voor het maken van een afspraak

Mail ons voor het maken van een afspraak

Ik ga akkoord met de privacyverklaring*