Pregabalin not effective in HIV neuropathy

Pregabalin was as effective as placebo and relatively well-tolerated in the treatment of painful HIV neuropathy, according to a new 2010 double-blind study.

79958728-Boygointer-Dreamstime-INP-Instituut-voor-Neuropathische-Pijn neuropathische pijn patientIn ‘Neurology’ neurologists of the Mount Sinai School of Medicine, New York, NY, USA reported the efficacy, safety, and tolerability of Pregabalin for treatment of painful HIV-associated neuropathy.

Double-blind study

The study followed a randomized, double-blind, placebo-controlled, parallel-group design using a flexible dose regime of 150-600 mg/day BID during 12-weeks.

The primary efficacy measure was the mean Numeric Pain Rating Scale (NPRS) score, an 11-point numeric rating scale.302 patients were randomized 151 on Pregabalin and 151 on placebo. Pregabalin average daily dosage was 385.7 mg/d.

Both Pregabalin and placebo showed some reductions in mean pain score from baseline: -2.88 vs -2.63, the difference was not clear. Somnolence and dizziness were the most common adverse events with pregabalin.

The authors concluded:

  • Pregabalin was well-tolerated, but not superior to placebo in the treatment of painful HIV neuropathy. Factors predicting analgesic response in HIV neuropathy warrant additional research. Classification of Evidence: This Class II trial showed that Pregabalin is not more effective than placebo in treatment of painful HIV neuropathy.[1]

Institute for Neuropathic Pain (INP)

This site helps patients and treating physicians, neurologists, anesthesiologists and other pain specialists to find the best and most up to date research findings related to neuropathy and neuropathic pain and the treatment thereof.

In our Institute we are specialized in treating patients suffering from neuropathic pain and neuropathy following an Integrated Medicine concept. Part of our activities are within the field of consultation. We assist pharmaceutical companies in R&D strategies related to finding new drugs to treat neuropathic pain and neuropathy.

February 2010, Jan M. Keppel Hesselink, MD, PhD.
‘Pregabalin not effective in HIV neuropathy’

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[1] Simpson DM, Schifitto G, Clifford DB, Murphy TK, Durso-De Cruz E, Glue P, Whalen E, Emir B, Scott GN, Freeman R; 1066 HIV Neuropathy Study Group. | Pregabalin for painful HIV neuropathy: a randomized, double-blind, placebo-controlled trial. | Neurology. | 2010 Feb 2;74(5):413-20.

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