Pregabalin not effective in HIV neuropathy
The study followed a randomized, double-blind, placebo-controlled, parallel-group design using a flexible dose regime of 150-600 mg/day BID during 12-weeks.
The primary efficacy measure was the mean Numeric Pain Rating Scale (NPRS) score, an 11-point numeric rating scale.302 patients were randomized 151 on Pregabalin and 151 on placebo. Pregabalin average daily dosage was 385.7 mg/d.
Both Pregabalin and placebo showed some reductions in mean pain score from baseline: -2.88 vs -2.63, the difference was not clear. Somnolence and dizziness were the most common adverse events with pregabalin.
The authors concluded:
- Pregabalin was well-tolerated, but not superior to placebo in the treatment of painful HIV neuropathy. Factors predicting analgesic response in HIV neuropathy warrant additional research. Classification of Evidence: This Class II trial showed that Pregabalin is not more effective than placebo in treatment of painful HIV neuropathy.
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February 2010, Jan M. Keppel Hesselink, MD, PhD.
‘Pregabalin not effective in HIV neuropathy’
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 Simpson DM, Schifitto G, Clifford DB, Murphy TK, Durso-De Cruz E, Glue P, Whalen E, Emir B, Scott GN, Freeman R; 1066 HIV Neuropathy Study Group. | Pregabalin for painful HIV neuropathy: a randomized, double-blind, placebo-controlled trial. | Neurology. | 2010 Feb 2;74(5):413-20.