Is een hoge dosis vitamine D veilig?

Is een hoge dosis vitamine D veilig en eventueel zinvol voor MS patienten?

In een studie van een jaar lang werden aan 25 Multiple Sclerose (MS) patiënten ultrahoge doseringen vitamine D gegeven, samen met calcium:[1]

In the year long open-label randomized trial, 25 MS patients received an escalated dose of vitamin D up to 40,000 IU over the first 28 weeks of the study (to assess tolerability). And then the dose was lowered to 10,000 IU for an additional 12 weeks. Followed by a further decrease back to 0 by the end of the year.
A control group of 24 MS patients took no or low doses (up to 4,000 IUs daily) of vitamin D. A daily dose of calcium (1,200 mg/d) was given throughout the study, the investigators reported online April 28 in advance of the print edition of Neurology.

Veilig, maar kleine studie

Die hoge doseringen bleken veilig te zijn volgens de onderzoekster:

Dr. Burton and her colleagues reported that vitamin D levels, even at those high levels, were safe and calcium levels were not abnormally altered. “That is always a concern when you deliver high doses of vitamin D,” she said.

De studie was slechts klein. Daarbij niet bedoeld om te onderzoeken of hoge doses vitamine D daadwerkelijk zinvol waren voor MS patiënten:

Dr. Burton said that although the study “was not powered or blinded to properly address clinical outcomes, clinical outcomes appeared to favor the treatment groups.” Specifically, they reported that T-cell reactivity and proliferation dropped in treated patients. In addition, there was a 41 percent reduction in relapse rates in the treated group compared with a 17 percent reduction in controls who were allowed to take up to 4,000 IUs of vitamin D daily.

Bron

Vitamin D in High Doses Found Safe — with Potential Benefits for MS, Neurology Today 10(11) June 2010: 27-28

Juni 2010en David J. Kopsky, artsen
‘Zijn hoge dosis vitamine D veilig?’

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Referentielijst

[1] Burton JM, Kimball S, Vieth R, Bar-Or A, Dosch HM, Cheung R, Gagne D, D'Souza C, Ursell M, O'Connor P. | A phase I/II dose-escalation trial of vitamin D3 and calcium in multiple sclerosis. | Neurology. | 2010 Jun 8;74(23):1852-9. Epub 2010 Apr 28.